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NARROW SPECTRUM ANTIBIOTICS

NARROW SPECTRUM ANTIBIOTICS: Uses, Advantages & Disadvantages

INTRODUCTION:

Antibiotics may be defined as the sub-group of anti-infective that are derived from bacterial sources and are used to treat bacterial infections.

An antibiotic may be classified basically as "narrow-spectrum" or "broad-spectrum" depending on the range of bacterial types that it affects. Narrow-spectrum antibiotics are active against a selected group of bacterial types. Broad-spectrum antibiotics are active against a wider number of bacterial types and, thus, may be used to treat a variety of infectious diseases.1

USES OF NARROW SPECTRUM ANTIBIOTICS:2

Narrow spectrum antibiotics are used for the specific infection when the causative organism is known.

ADVANTAGES OF NARROW SPECTRUM ANTIBIOTICS:2

  • The narrow-spectrum antibiotic will not kill as many of the normal microorganisms in the body as the broad spectrum antibiotics. So, It has less ability to cause superinfection.
  • The narrow spectrum antibiotic will cause less resistance of the bacteria as it will deal with only specific bacteria.
DISADVANTAGES OF NARROW SPECTRUM ANTIBIOTICS:

  • Narrow spectrum antibiotics can be used only if the causative organism is identified.
  • If you don't choose the drug very carefully, the drug may not actually kill the microorganism causing the infection.
NARROW SPECTRUM ANTIBIOTICS:
  • Azithromycin
  • Clarithromycin
  • Clindamycin
  • Erythromycin
  • Vancomycin
AZITHROMYCIN:3

Azithromycin is a azalide, a subclass of macrolide antibiotic.

Indication:

Bacterial infections,those causing,
  • middle ear infections,
  • tonsillitis,
  • throat infections,
  • laryngitis,
  • bronchitis,
  • pneumonia,
  • Typhoid,
  • sinusitis.
  • Urinary tract infections
Presentation:

AzithromycinDry Powder Suspension100mg
AzithromycinTablets 250mg, 500mg
AzithromycinLyophilised Injection500mg


CLARITHROMYCIN:4

Clarithromycin is a macrolide antibiotic which works by interfearing with the protein synthesis of the bacteria.

Indication:
  • pharyngitis,
  • tonsillitis,
  • acute maxillary sinusitis,
  • acute bacterial exacerbation of chronic bronchitis,
  • pneumonia,
  • skin structure infections
Presentation:

Clarithromycin Tablets 250mg, 500mg


CLINDAMYCIN:4

Clindamycin is lincosamine antibiotic.

Clindamycin has a bacteriostatic effect. It is a bacterial Protein synthesis inhibitor. It does so by binding preferentially to the 23S subunit of the bacterial 50s ribosome.

Indication:
  • Clindamycin is used primarily to treat infections caused by susceptible anaerobic bacteria, including infections of the respiratory tract, skin and soft tissue infections, and peritonitis
  • In patients with hypersensitivity to penicillins, clindamycin may be used to treat infections caused by susceptible aerobic bacteria as well.
  • It is also used to treat bone and joint infections, particularly those caused by Staphylococcus aureus.
Presentation:

Clindamycin Injection300mg/2ml, 600mg/4ml
Clindamycin + Benzoyl PeroxideGel1% + 5%


ERYTHROMYCIN:5

Erythromycin is a Macrolide antibiotic.

Mechanism Of Action:

Erythromycin is a bactericidal.Erythromycin inhibit protein synthesis by binding to the 23S rRNA molecule (in the 50S subunit) of the bacterial ribosome blocking the exit of the growing peptide chain of sensitive microorganisms.

Indication:
  • Acute Bacterial Sinusitis,
  • Acute Otitis Media Infection,
  • Acute Streptococcal Pyogenes Bacterial Sinusitis,
  • Acute Streptococcus Pneumoniae Bacterial Sinusitis,
  • Bacterial Pneumonia,
  • Chlamydia Cervicitis,
  • Chlamydial Conjunctivitis,
  • Chlamydia Trachomatis Urethritis,
  • Diphtheria, Diphtheria Prevention,
  • Listeriosis,
  • Mycoplasmal Pneumonia,
  • Neonatal Pneumonia,
  • Nongonococcal Urethritis,
  • Pertussis,
  • Pharyngitis due to Streptococcus Pyogenes,
  • Pneumococcal Pharyngitis
  • Skin Infections
Presentation:

ErythromycinTablets125mg, 250mg, 500mg


VANCOMYCIN:3

Vancomycin is a glycopeptide antibiotic. Vancomycin is used for the treatment of infection caused by Gram-positive bacteria.

Vancomycin acts by inhibiting the bacterial cell wall synthesis.

Indication:
  • Pseudomembranous enterocolitis caused by C. difficile,
  • Serious MRSA Infection,
  • Enterococcal endocarditis,
  • Penicillin resistant pneumococcal infections,
  • Infections caused by diphtheroids.
Presentation:

Vancomycin Lyophilised Injection500mg, 1g


SRS PRODUCTS ON NARROW SPECTRUM ANTIBIOTICS:

Active Ingrediant FormStrength Pack TypePacking Style

Azithromycin

Dry Powder Suspension

100mg

Sachet

10's

Azithromycin

Tablets

250mg, 500mg

Blister

10's

Azithromycin

Lyophilised Injection

500mg

Vial

10ml Vial

Clarithromycin

Tablets

250mg, 500mg

Blister

10's

Clindamycin

Injection

300mg/2ml, 600mg/4ml

Ampoule

2ml, 4ml

Clindamycin + Benzoyl Peroxide

Gel

1% +5%

Tube

45g

Erythromycin

Tablets

125mg, 250mg, 500mg

Blister

10's

Vancomycin

Lyophilised Injection

500mg, 1g

Vial

10ml, 20ml Vial



Reference


Important: The drug information on this Web page is meant to be educational. It is not a substitute for medical advice. Please see your health care professional for more information about your specific medical condition and the use of the above mentioned drug.
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