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ANTINEOPLASTIC AGENTS / ANTICANCER DRUGS

INTRODUCTION OF ANTINEOPLASTIC AGENTS / ANTICANCER DRUGS:

Antineoplastics or Anticancer drugs are the drugs that prevent or inhibit the maturation and proliferation of neoplasms.

Antineoplastic agents travel the body and destroy cancer cells. Many of the side effects associated with antineoplastic agents occur because treatment destroys the body's normal cells in addition to cancerous cells.

General Toxicities of Antineoplastic / Anticancer Drugs are:
  • Bone marrow depression
  • Lymphocytopenia
  • GIT Stomatitis
  • Diarrhoea
  • Nausea and Vomiting
  • Alopecia
  • Hyperuricaemia
  • Hair loss
Antineoplastic drugs / Anticancer Drugs are not only used prominently in different types of cancers but also in conjunction with surgery, radiotherapy and immunotherapy in the combined modality approach for many solid tumors, especially metastatic.

Types of Cancer

Types of CancerAffected Area
Anal cancerAnus
Breast CancerBreast
Bladder CancerUrinary Bladder
Bone marrow CancerShafts of long bones
Colon CancerColon
Cervical CancerCervix
Eye CancerEye
Gynecological CancerFemale Reproductive organs
Lung CancerLung
Osteo sarcomametaphyseal region of tubular long bones
Wilms tumourKidney
LeukemiaBlood
Larynx CancerLarynx
Testicular cancerTestis
Rectal CancerRectum


Classification of Antineoplastic Agents / Anticancer Drugs 2

  1. Alkylating Agents
    • Nitrogen mustards: Melphalan, Cyclophosphamide, Ifosfamide
    • Nitrosoureas
    • Alkylsulfonates
    • Ethyleneimines
    • Triazene
    • Methyl Hydrazines
    • Platinum Coordination complexes: Cisplatin, Carboplatin, Oxaliplatin
  2. Antimetabolites
    • Folate Antagonists: Methotrexate
    • Purine antagonists
    • Pyrimidine antagonists: 5-Fluorouracil, Cytarabibe
  3. Natural Products
    1. Plant Products
      • Vinca Alkaloids: Vincristine, Vinblastine
      • Taxanes: Paclitaxel, Docetaxel
      • Epipodophyllotoxins: Etoposide
      • Camptothecins: Irinotecan
    2. Microorganism Products
      • Antibiotics: Doxorubicin, Bleomycin
      • Enzymes: L-Asparaginase
  4. Miscellaneous
    • Hydroxyurea
    • Imatinib Mesylate
    • Rituximab
    • Epirubicin
    • Bortezomib
    • Zoledronic Acid
    • Geftinib
    • Leucovorin
    • Pamidronate
    • Gemcitabine
  5. Hormones and Antagonists
    • Corticosteroids: Prednisone, Dexamethasone
    • Estrogens: Ethinyloestradiol
    • Antiestrogens: Tamoxifen
    • Progesteron derivative: Megestrol Acetate
    • Androgen: Testosterone propionate
    • Antiandrogen: Flutamide , Bicalutamide
    • Aromatase inhibitor: Letrozole , Anastrazole
    • 5-alpha reductase inhibitor: Finasteride
    • GnRH Analogue: Leuprolide, Buserelin
    • Growth Hormone, glucagon and insulin inhibitor: Octreotide

SRS Antineoplastic Products / Anticancer Drugs:

Sr. No.Product (INJECTION)Spec.StrengthsPack Size
1Cyclophosphamide InjectionBP,USP200mg, 500mg, 1gm1 vial
2Methotrexate InjectionBP25mg 1 vial
3Fluorouracil Injectrion BP50mg1x5 amp
4Cisplatin Injection BP1mg1 vial
5Doxorubicin Hydrochloride InjectionBP,USP2mg1 vial
6Doxorubicin Hydrochloride for InjectionBP,USP2mg1 vial
7Irinotecan Hydrochloride Injection IP20mg1 vial
8Carboplatin InjectionBP10mg1 vial
9Vincristine Sulfate InjectionUSP1mg1 vial
10Gemcitabine for Injection USP200mg, 1gm1 vial
11Bleomycin for InjectionUSP15 units1 vial
12Paclitaxel InjectionUSP30mg,100mg,260m1 vial
13Epirubicin Hydrochloride for InjectionInhouse10mg, 50mg, 100mg1 vial
14Etoposide Injection USP20mg1 vial
15Docetaxel Injection Concentrate Inhouse20mg,80mg,120mg1 vial
16Solvent for Docetaxel Injection Concentrate Inhouse1.5ml, 3ml, 6ml, 9ml1 vial
17Pegylated Doxorubicin HCl liposome Injection Inhouse10ml,1 vial
18Zoledronic Acid for InjectionInhouse4mg1 vial
19Vinblastine Sulphate for InjectionBP10mg 1 vial
20Oxaliplatin Injection Inhouse1 vial
21L-Asparaginase for InjectionInhouse5000 IU, 10000 IU1 vial
22Fludarabine Phosphate for InjectionUSP50mg1 vial
23Octreotide Injection Inhouse50mcg, 100mcg1 amp


Sr. No.Product (TABLETS)Spec.StrengthsPack Size (Strip)
1Tamoxifen Citrate Tablets BP,USP10mg, 20mg10's
3Methotrexate Tablets BP

2.5mg, 5.0mg, 7.5mg

10's
5Bicalutamide Tablets USP50mg10's
6Anastrozole Tablets Inhouse1mg10's
7Letrozole Tablets USP2.5mg 10's
8Gefitinib Tablets Inhouse250mg10's
9Fludarabine Phosphate TabletsInhouse10mg 10's
11Flutamide Tablets Inhouse250mg10's


Sr. No.Product (CAPSULES)Spec.StrengthsPack Size
1Hydroxyurea Capsules USP500mg10's strip
2Imatinib Capsules Inhouse100mg, 400mg10's jar
3Temozolomide CapsulesInhouse20mg, 100mg, 250mg5's jar
4Etoposide Capsules IP,USP50mg, 100mg4's, 8's jar

References


Important: The drug information on this Web page is meant to be educational. It is not a substitute for medical advice. Please see your health care professional for more information about your specific medical condition and the use of the above mentioned drug.
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